As in MIL-STD-1760, EBR-1553 does not support RT-to-RT transfers.

EBR-1553 does not have redundancy, only bus A. However, a munition can support two RTs, and by that provide redundancy. 

RS-485 transceivers are not ground floating like legacy-1553 is, and thus less robust.

There is no formal RT-Validation testing in EBR-1553. This reduces the interoperability between vendors. As a result, there are two known variants of the EBR-1553 signal shape, one for Lockheed and another for Boeing. A decoder that supports both is required.  

Transformers in legacy-1553 systems are better immune to lightning than ground referenced physical layers.